Antonio Carlos Freitas dos Santos

Research Assistant Professor

Biography

Antonio C. F. dos Santos is a Research Assistant Professor in the Department of Engineering at °¬¿ÉÖ±²¥ College. His research involves developing processes with cells and proteins for multiple applications from first conception to industrial scale production. The industries his work has contributed to include biofuels, bioproducts, tissue engineering and drug development. His current work with the Gaudette Lab focuses on cellular agriculture and tissue engineering to treat skin injuries. Dr. dos Santos enjoys mentoring students and working with undergraduates in the lab to explore research opportunities related to bioprocessing and tissue engineering.

Prior to joining °¬¿ÉÖ±²¥ College, Antonio was a postdoctoral researcher at the Laboratory of Renewable Resources Engineering at Purdue University, working on drug development and biomass liquefaction. He earned his Ph.D. at Purdue in the Department of Agricultural and Biological Engineering. His doctoral research explored the challenges of biomass handling and transformation at high concentrations that are needed at industrial scale.

Representative Publications

  • Thyden, R., Dominko, T., Weathers, P., dos Santos, A.C.F., Perreault, L., Reddig, D., Kloster, J., Gaudette, G. Recycling spent animal cell culture media using the thermally resistant microalga Chlorella sorokiniana. System Microbiology and Biomanufacturing. 2024. https://doi.org/10.1007/s43393-024-00280-w
  • Chen, X., dos Santos, A. C. F., Gutierrez, D. M. R., Zhang, S., Aston, J. E., Thompson, D. N., Ladisch, M.R., Mosier, N. S. Understanding the Influence of Water-Soluble Compounds from Unpretreated Corn Stover Pellets on Enzymatic Hydrolysis of Cellulose. ACS Sustainable Engineering. 2023. https://doi.org/10.1021/acssuschemeng.3c04222
  • dos Santos, A.C.F.; Ahmadzadegan, A.; Ximenes, E.; Vlachos, P.; Ardekani, A.; Kapur, S.; Corvari, V.; Ladisch, M.R. Concentration dependent diffusion of unlabeled protein within an in vitro hyaluronic acid matrix. Biotechnology and Bioengineering. 2023, 120.8, 2326–2332. https://doi.org/10.1002/bit.28505
  • dos Santos, A.C.F.; Ahmadzadegan, A.; Ximenes, E.; Vlachos, P.; Ardekani, A.; Kapur, S.; Corvari, V.; Ladisch, M.R. In vitro Measurement of Concentration of Unlabeled Protein within a Hyaluronic Acid Matrix. Biotechnology and Bioengineering. 2022. 119(12), 3647–3656. https://doi.org/10.1002/bit.28243 
  • dos Santos, A.C.F.; Overton, J.C.; Szeto, R.; Patel, M.H.; Gutierrez, D.M.; Eby, C.; Moreno, A.M.M.; Erk, K.A.; Aston, J.E.; Thompson, D.N.; Dooley, J.H.; Sharma, P.; Mosier, N.S.; Ximenes, E.; Ladisch, M.R. New Strategy For Liquefying Corn Stover Pellets. Bioresource Technology. 2021, 341, 125773. https://doi.org/10.1016/j.biortech.2021.125773
  • dos Santos, A.C.F; Ximenes, E.; Thompson, D.; Ray, A.E.; Szeto, R.; Erk, K.; Dien, B.; Ladisch, M.R. Effect Of Using A Nitrogen Atmosphere On Enzyme Hydrolysis At High Corn Stover Loadings In An Agitated Reactor. Biotechnology Progress. 2020, 36(6), e3059. https://doi.org/10.1002/btpr.3059