Biology Department Faculty

Thomas N. Seyfried

Professor

Photo of Thomas N. Seyfried

Thomas N. Seyfried

Ph.D.

Contact

Higgins Hall 514

Telephone: 617-552-3563

Email: thomas.seyfried@bc.edu

ORCID

Education

  • Ph.D., University of Illinois, Urbana-Champaign

Research Interests

Gene-Environmental Interactions, Lipid Biochemistry, Neurodegeneration, Ganglioside Storage Diseases, Epilepsy, Cancer, Metabolism, Brain Tumors, Autism, Ketogenic Diets, Dietary Energy Restriction

Department

Biology

Research

Our research program focuses on mechanisms by which metabolic therapy manages chronic diseases such as epilepsy, neurodegenerative lipid storage diseases, and cancer. The metabolic therapies include caloric restriction, fasting, and ketogenic diets. 聽Our approach is based on the idea that compensatory metabolic pathways are capable of modifying the pathogenesis of complex diseases. Global shifts in metabolic environment can neutralize molecular pathology. In the case of cancer, these therapies target and kill tumor cells while enhancing the physiological health of normal cells. The neurochemical and genetic mechanisms of these phenomena are under investigation in novel animal models and include the processes of inflammation, cellular physiology, angiogenesis, and lipid biochemistry.

Selected Publications

  • Doczi, J., Noemi Karnok, David Bui, Victoria Azarov, Gergely Pallag, Sara Nazarian, Bence Czumbel, Thomas N. Seyfried, Christos Chinopoulos.听 . Sci Rep.听2023;聽13: 10822.听聽Published online聽2023聽Jul 4.听doi:聽10.1038/s41598-023-37677-x
  • Seyfried, TN., Purna Mukherjee, Derek C. Lee, Linh Ta, Loren Nations. .听 Front Nutr.听2023;聽10: 1157517.听聽Published online聽2023聽Mar 28.听doi:聽10.3389/fnut.2023.1157517
  • Seyfried TN. Nat Rev Urol. 2022 Jul;19(7):389-390. doi: 10.1038/s41585-022-00612-2.PMID:聽35676538.
  • Seyfried TN, Arismendi-Morillo G, Zuccoli G, Lee DC, Duraj T, Elsakka AM, Maroon JC, Mukherjee P, Ta L, Shelton L, D'Agostino D, Kiebish M, Chinopoulos C.听 Front Oncol. 2022 Aug 17;12:968351. doi: 10.3389/fonc.2022.968351. eCollection 2022.PMID:聽36059707
  • Seyfried TN, Shivane AG, Kalamian M, Maroon JC, Mukherjee P, Zuccoli G. 聽 Front Nutr. 2021 May 31;8:682243. doi:10.3389/fnut.2021.682243. eCollection 2021.PMID:聽34136522
  • Seyfried TN, Mukherjee P, Lee DC, Ta L, Nations L.听 聽 Front Nutr. 2023 Mar 28;10:1157517. doi: 10.3389/fnut.2023.1157517. eCollection 2023.PMID:聽37057065
  • Seyfried TN, Arismendi-Morillo G, Zuccoli G, Lee DC, Duraj T, Elsakka AM, Maroon JC, Mukherjee P, Ta L, Shelton L, D'Agostino D, Kiebish M, Chinopoulos C. Front Oncol. 2022 Aug 17;12:968351. doi: 10.3389/fonc.2022.968351. PMID:聽36059707
  • Evangeliou AE, Spilioti MG, Vassilakou D, Goutsaridou F,聽Seyfried TN.聽 Restricted Ketogenic Diet Therapy for Primary Lung Cancer With Metastasis to the Brain: A Case Report.听 Cureus. 2022 Aug 2;14(8):e27603. doi: 10.7759/cureus.27603. eCollection 2022 Aug.PMID:聽36059366
  • Pallag G, Nazarian S, Ravasz D, Bui D, Koml贸di T, Doerrier C, Gnaiger E,聽Seyfried TN, Chinopoulos C. 聽 Int J Mol Sci. 2022 May 4;23(9):5111. doi: 10.3390/ijms23095111.PMID:聽35563503
  • Duraj T, Carri贸n-Navarro J,聽Seyfried TN, Garc铆a-Romero N, Ayuso-Sacido A.. Mol Metab. 2021 Dec;54:101389. doi: 10.1016/j.molmet.2021.101389. Epub 2021 Nov 5.PMID:聽34749013
  • Seyfried TN, Chinopoulos C. Metabolites. 2021 Aug 25;11(9):572. doi: 10.3390/metabo11090572.PMID:聽34564387
  • Jiang Y, Yang X, Dong C, Lu Y, Yin H, Xiao B, Yang X, Chen W, Cheng W, Tian H, Guo L, Hu X, Fang H, Chen W, Li Z, Zhou W, Sun W, Guo X, Li S, Lin Y, He R, Chen X, Liu D, Zhang M, Zhang Y, Zhao H, Zheng P,聽Seyfried TN, Hoffman RM, Jia W, Ji G, Jia L. Clin Transl Med. 2021 Aug;11(8):e502. doi: 10.1002/ctm2.502.PMID:聽34459130
  • Gross AL, Gray-Edwards HL, Bebout CN, Ta NL, Nielsen K, Brunson BL, Mercado KRL, Osterhoudt DE, Batista AR, Maitland S,聽Seyfried TN, Sena-Esteves M, Martin DR. Brain. 2021 Aug 19:awab309. doi: 10.1093/brain/awab309. Online ahead of print.PMID:聽34410345.
  • Gabriele VR, Mazhabi RM, Alexander N, Mukherjee P,聽Seyfried TN, Nwaji N, Akinoglu EM, Mackiewicz A, Zhou G, Giersig M, Naughton MJ, Kempa K.
    Pharmaceutics. 2021 Jun 26;13(7):965. doi: 10.3390/pharmaceutics13070965.PMID:聽34206894聽
  • 陌yikesici MS, Slocum AK, Winters N, Kalamian M,聽Seyfried TN. Cureus. 2021 Apr 26;13(4):e14686. doi: 10.7759/cureus.14686.PMID:聽33927959.
  • Lee TS, Li AY, Rapuano A, Mantis J, Eid T,聽Seyfried TN, de Lanerolle NC聽 Neurobiol Dis. 2021 Jan;147:105152. doi: 10.1016/j.nbd.2020.105152.
  • Seyfried TN, Arismendi-Morillo G, Mukherjee P, Chinopoulos C. iScience. 2020 Nov 2;23(11):101761. doi: 10.1016/j.isci.2020.101761.
  • Thomas N. Seyfried, Laura Shelton, Gabriel Arismendi鈥慚orillo, Miriam Kalamian, Ahmed Elsakka, Joseph Maroon, Purna Mukherjee. Springer Science+Business Media, LLC, part of Springer Nature 2019 Received: 22 January 2019 / Revised: 3 April 2019 / Accepted: 4 April 2019
  • Christos Chinopoulos and Thomas N. Seyfried. . ASN Neuro | (2019) 2:200 | https://doi.org/10.1038/s42003-019-0455-x | www.nature.com/commsbio
  • Purna Mukherjee, Zachary M. Augur, Mingyi Li, Collin Hill, Bennett Greenwood, Marek A. Domin, Gramoz Kondakci, Niven R. Narain, Michael A. Kiebish, Roderick T. Bronson, Gabriel Arismendi-Morillo, Christos Chinopoulos & Thomas N. Seyfried. COMMUNICATIONS BIOLOGY | (2019) 2:200 | https://doi.org/10.1038/s42003-019-0455-x | www.nature.com/commsbio
  • Zachary M. Augur, Catherine M. Doyle, Mingyi Li, Purna Mukherjee and Thomas N. Seyfried. Front. Nutr., 05 October 2018.
  • Taus LJ, Flores RE, Seyfried TN. Cancer Lett. 2017 Oct 1;405:56-62. doi: 10.1016/j.canlet. 2017.07.011.
  • Klement RJ, Feinman RD, Gross EC, Champ CE, D'Agostino DP, Fine EJ, K盲mmerer U, Poff A, Rho JM, Seyfried TN, Scheck AC. Med Oncol. 2017 Jun;34(6):108. doi: 10.1007/s12032-017-0968-4.
  • Arismendi-Morillo G, Castellano-Ram铆rez A, Seyfried TN. Ultrastruct Pathol. 2017 May-Jun;41(3):234-244. doi: 10.1080/01913123.2017.1300618.
  • Puchowicz MA, Seyfried TN. J Neurochem. 2017 Apr;141(2):162-164. doi: 10.1111/jnc.
  • Seyfried TN, Yu G, Maroon JC, D'Agostino DP. Nutr Metab (Lond). 2017 Feb 23;14:19. doi: 10.1186/s12986-017-0178-2. eCollection 2017. PMID: 28250801
  • Chen E, Kiebish MA, McDaniel J, Gao F, Narain NR, Sarangarajan R, Kacso G, Ravasz D, Seyfried TN, Adam-Vizi V, Chinopoulos C. Biochim Biophys Acta. 2016 Nov;1861(11):1727-1735. doi: 10.1016/j.bbalip.2016.08.007.
  • Schneider JS, Seyfried TN, Choi HS, Kidd SK. PLoS One. 2015 Dec 2;10(12):e0143351. doi: 10.1371/journal.pone.0143351
  • Ta NL, Seyfried TN. Lipids. 2015 Dec;50(12):1167-84.
  • Seyfried TN. Front Cell Dev Biol. 2015 Jul 7;3:43.
  • Akgoc Z, Iosim S, Seyfried TN. Lipids. 2015 Sep;50(9):907-12.
  • Poff AM, Ward N, Seyfried TN, Arnold P, D'Agostino DP. PLoS One. 2015 Jun 10;10(6):e0127407.
  • Maroon JC, Seyfried TN, Donohue JP, Bost J. Surg Neurol Int. 2015 Apr 16;6:61.听
  • Rockwell HE, McCurdy VJ, Eaton SC, Wilson DU, Johnson AK, Randle AN, Bradbury AM, Gray-Edwards HL, Baker HJ, Hudson JA, Cox NR, Sena-Esteves M, Seyfried TN, Martin DR. ASN Neuro. 2015 Apr 13;7(2).
  • Meidenbauer JJ, Mukherjee P, Seyfried TN. n Nutr Metab (Lond). 2015 Mar
  • Akgoc Z, Sena-Esteves M, Martin DR, Han X, d'Azzo A, Seyfried TN. J Lipid Res. 2015 May;56(5):1006-13. 聽
  • Heinecke KA, Luoma A, d'Azzo A, Kirschner DA, Seyfried TN.
  • ASN Neuro. 2015 Feb 18;7(1). 聽
  • McCurdy VJ, Rockwell HE, Arthur JR, Bradbury AM, Johnson AK, Randle AN, Brunson BL, Hwang M, Gray-Edwards HL, Morrison NE, Johnson JA, Baker HJ, Cox NR, Seyfried TN, Sena-Esteves M, Martin DR. 聽Gene Ther. 2015 Feb;22(2):181-9.听
  • Maroon JC, Seyfried TN, Donohue JP, Bost J. Surg Neurol Int. 2015 Apr 16;6:61.
  • Rockwell HE, McCurdy VJ, Eaton SC, Wilson DU, Johnson AK, Randle AN, Bradbury AM, Gray-Edwards HL, Baker HJ, Hudson JA, Cox NR, Sena-Esteves M, Seyfried TN, Martin DR. ASN Neuro. 2015 Apr 13;7(2).
  • Meidenbauer JJ, Mukherjee P, Seyfried TN. Nutr Metab (Lond). 2015 Mar 11;12:12.
  • Akgoc Z, Sena-Esteves M, Martin DR, Han X, d'Azzo A, Seyfried TN.
  • J Lipid Res. 2015 May;56(5):1006-13.
  • Heinecke KA, Luoma A, d'Azzo A, Kirschner DA, Seyfried TN. ASN Neuro. 2015 Feb 18;7(1).
  • McCurdy VJ, Rockwell HE, Arthur JR, Bradbury AM, Johnson AK, Randle AN, Brunson BL, Hwang M, Gray-Edwards HL, Morrison NE, Johnson JA, Baker HJ, Cox NR, Seyfried TN, Sena-Esteves M, Martin DR. Gene Ther. 2015 Feb;22(2):181-9.
  • Seyfried TN, Flores R, Poff AM, D'Agostino DP, Mukherjee P. Cancer Lett. 2015 Jan 28;356(2 Pt A):289-300.
  • Mattson MP, Allison DB, Fontana L, Harvie M, Longo VD, Malaisse WJ, Mosley M, Notterpek L, Ravussin E, Scheer FA, Seyfried TN, Varady KA, Panda S. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16647-53.
  • Seyfried TN, Rockwell HE, Heinecke KA, Martin DR, Sena-Esteves M. Adv Neurobiol. 2014; 9:485-99.
  • Seyfried TN.
  • J Lipid Res. 2014 Sep; 55(9): 1815-7.
  • Mantis JG, Meidenbauer JJ, Zimick NC, Centeno NA, Seyfried TN.
  • Epilepsy Res. 2014 Sep; 108(7): 1137-44.
  • Meidenbauer JJ, Ta N, Seyfried TN.
  • Nutr Metab (Lond). 2014 May 22; 11:23.
  • Poff AM, Ari C, Arnold P, Seyfried TN, D'Agostino DP. n Int J Cancer. 2014 Oct 1;135(7):1711-20.
  • Dufort FJ, Gumina MR, Ta NL, Tao Y, Heyse SA, Scott DA, Richardson AD, Seyfried TN, Chiles TC. J Biol Chem. 2014 Mar 7;289(10):7011-24.
  • Seyfried TN, Flores RE, Poff AM, D'Agostino DP. Carcinogenesis. 2014 Mar;35(3):515-27.
  • Ta NL, Jia X, Kiebish M, Seyfried TN. Lipids. 2014 Jan;49(1):113-7.
  • Ahmed SS, Li H, Cao C, Sikoglu EM, Denninger AR, Su Q, Eaton S, Liso Navarro AA, Xie J, Szucs S, Zhang H, Moore C, Kirschner DA, Seyfried TN, Flotte TR, Matalon R, Gao G.
  • Mol Ther. 2013 Dec;21(12):2136-47.
  • Poff AM, Ari C, Seyfried TN, D'Agostino DP.
  • PLoS One. 2013 Jun 5;8(6):e65522.
  • Bradbury AM, Cochran JN, McCurdy VJ, Johnson AK, Brunson BL, Gray-Edwards H, Leroy SG, Hwang M, Randle AN, Jackson LS, Morrison NE, Baek RC, Seyfried TN, Cheng SH, Cox NR, Baker HJ, Cach贸n-Gonz谩lez MB, Cox TM, Sena-Esteves M, Martin DR. Mol Ther. 2013 Jul;21(7):1306-15.
  • Arthur JR, Wilson MW, Larsen SD, Rockwell HE, Shayman JA, Seyfried TN. Neurochem Res. 2013 Apr;38(4):866-75.

Media

YouTube

聽- Thomas Seyfried (June 2018)

Podcast

鈥�.

Donations

If you would like to show your support for the research Dr. Seyfried and his lab undertake, you can easily contribute a donation through聽. Please select the "Area of Support*" section, scroll down and choose the "Other" category, and type in "Biology Cancer Research - Dr. Seyfried" in the text field. Contributions of any size are welcome.

Treatise

Dr. Seyfried published a groundbreaking treatise entitled,聽Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer聽(Wiley, 1st ed., 2012). The treatise provides extensive information showing that cancer can be best defined as a mitochondrial metabolic disease rather than as a genetic disease.听This new concept has implications for the development of new non-toxic cancer therapies including the ketogenic diet. Experts in the cancer research field have praised this comprehensive study as one of science's hottest topics.听.

Presentations

Dr. Seyfried has been a featured speaker at numerous scientific symposia and conferences relating to cancer, including the 2nd Annual Ancestral Health Symposium, 2012;聽The聽Educational Session Lecture, American Association Cancer Research, 2013, and聽the聽Institute for Human & Machine Cognition (IHMC), 2015. To view his IHMC lecture, 鈥淐ancer: A Metabolic Disease With Metabolic Solutions鈥�, .听

Editorial Boards

  • ASN NEURO, Senior Editor
  • Journal of Lipid Research
  • Neurochemical Research
  • Nutrition & Metabolism
  • Frontiers in Nutrition
  • Frontiers in Oncology

Awards

  • Alumni Achievement Award, University of New England, 2013
  • Lifetime Achievement Award, 2016 - Academy of Comprehensive and Complementary Medicine
  • Mercola Gamechanger Award, 2016
  • American College of Nutrition Award Lecture winner, 2017
  • 2019 Outstanding Career Achievement Award in the Field of Dose Response.听 International Dose Response Society.
Back To Top