Chemistry Department Faculty
Jianmin Gao
Professor of Chemistry
Jianmin Gao
Ph.D.
Contact
Merkert Center 203
Telephone: 617-552-0326
Email: jianmin.gao@bc.edu
ORCID
Education
- Ph.D., Stanford University
Research Interests
Synthetic probes of membrane lipids and their modifications pertinent to disease.
Research
The Gao lab works in the general areas of organic chemistry and chemical biology. Specifically, we are interested in understanding and ultimately gaining control over the functions of cell membranes. As a defining feature of a cell, the cell membrane hosts close to one third of the entire proteome and mediates numerous signaling pathways. Our lab uses organic synthesis to create novel peptides and peptidomimetics that functionally mimic natural membrane proteins, including channel formers and lipid-targeting proteins. Research activities as such allow us to elucidate new chemical principles of protein-membrane interactions. Synthetic molecules that are active on biomembranes may also serve as novel antibiotics and tumor imaging agents.
Representative Key Publications:
- Sam Cambray and聽Jianmin Gao*, 鈥淰ersatile Conjugation Chemistries of ortho-Boronyl Aryl Ketones and Aldehydes,鈥澛�Acc. Chem. Res.,听2018,听51, 2198-206.
- Kelly A. McCarthy, Michael A. Kelly, Kaicheng Li, Samantha Cambray, Azade Hosseini,听 Tim van Opijnen, and聽Jianmin Gao*, 鈥淧hage display of dynamic covalent binding motifs enables facile development of targeted antibiotics,鈥澛�J. Am. Chem. Soc.,听2018,听140, 6137-45.
- Anupam Bandyopadhyay,#聽Samantha Cambray,#听补苍诲听Jianmin Gao*, 鈥淔ast diazaborine formation of semicarbazide enables facile labeling of bacterial pathogens,鈥澛�J. Am. Chem. Soc.,听2017,听139, 871-8.
- Anupam Bandyopadhyay, Kelly A. McCarthy, Michael A. Kelly and聽Jianmin Gao*, 鈥淭argeting Bacteria via Iminoboronate Chemistry of Amine-Presenting Lipids,鈥澛�Nat. Commun.,听2015, DOI: 10.1038/ncomms7561.