Biology Department Faculty

Thomas Chiles

Professor and Deluca Chair of Biology

Vice Provost for Research & Academic Planning

Photo of Thomas Chiles

Thomas Chiles

Ph.D.

Contact

Higgins Hall 544B

Telephone: 617-552-0840

Email: thomas.chiles@bc.edu

Education

  • Ph.D., University of Florida

Department

Biology

Research

The laboratory is interested in understanding how extrinsic signals influence B lymphocyte growth and survival. We are currently focused on investigating the regulation and function of D-type cyclins in splenic B-2 and peritoneal B-1a cells in response to B-cell antigen receptor engagement. Effort is also directed toward investigating the bioenergetics underlying B-2 lymphocyte survival, specifically identifying signaling and nutrient energy metabolic pathways linked to IL-4 receptors. Specifically, we are using 13C-glucose/13C-glutamine together with 2D-NMR and mass spectrometry to elucidate metabolic pathways that support lymphocyte survival. We are also designing novel carbon nanotube structures in order to efficiently introduce macromolecules (e.g., siRNAs, genes, proteins) into primary B lymphocytes. Additional interests are directed toward developing nanosensors for multiplex detection of disease biomarkers (e.g., cancer and infectious diseases).

Selected Publications

  • Archibald, M.M., Rizal, B., Connolly, T., Burns, M.J., Naughton, M.J., Chiles, T.C. 2015. . Biosens. Bioelectron. 74:406-410.
  • Dufort FJ, Gumina MR, Ta NL, Tao Y, Heyse SA, et al. . J Biol Chem. 2014 Mar 7;289(10):7011-24. PubMed PMID: ; PubMed Central PMCID: .
  • Rizal B, Archibald MM, Connolly T, Shepard S, Burns MJ, et al. . Anal Chem. 2013 Nov 5;85(21):10040-4. PubMed PMID:
  • Blair D, Dufort FJ, Chiles TC, 2012. . Biochem J. 448(1):165-9.
  • Zhao H, Rizal B, McMahon G, Wang H, Dhakal P, Kirkpatrick T, Ren Z, Chiles TC, Naughton MJ, Cai D. 2012. . ACS Nano. 6(4):3171-8.
  • Jammallo L, Eidell K, Davis PH, Dufort FJ, Cronin C, Thirugnanam S, Chiles TC, Roos DS, Gubbels MJ. 2011. . Mol Biochem. Parasitol. 175(2):133-43.
  • Crane, M.T. and聽Chiles, T.C. 2011. Why the Liberal Arts Need the Sciences (and Vice Versa). Commentary. The Chronicle of Higher Education. Nov. 13.
  • Strelko, C.L., Lu, W., Dufort, F.J., Seyfried, T.N., Chiles, T.C., Rabinowitz, J.D., and Roberts, M.F. 2011. Itaconic acid, a polymer building block, is a novel mammalian metabolite induced during macrophage activation. J. Am. Chem. Soc. 133:16386-16389.
  • Jammallo, L., Eidell, K., Davis, P.H., Dufort, F.J., Cronin, C., Thirugnanam, S., Chiles, T.C., Roos, D.S., and Gubbels, M.J. 2010. . Mol. Biochem. Parasitol. 175:133-143.
  • Gumina, M.R., Xu, C., Chiles, T.C. 2010. Cell Cycle 9(4): 820鈥�828. Epub 2010, Mar. 2.
  • Yu, Y., Cimeno, A., Lan, Y.C., Rybczynski, J., Wang, D.Z., Paudel, T., Ren, Z.F., Wagner, D.J., Qiu, M.Q., Chiles, T.C., and Cai, D. 2009. . Micro & Nano Letters 4(1): 27鈥�33.
  • Cai, D., Blair, D., Dufort, F.J., Gumina, M.R., Huang, Z., Hong, G., Wagner, D., Canahan, D., Kempa, K., Ren, Z.F., and Chiles, T.C. 2008. . Nanotechnology 19(34): 1鈥�10.
  • Wang, Y.K., Chen, W., Blair, D., Pu, M., Xu, Y., Miller, S.J., Redfield, A.G., Chiles, T.C., Roberts, M.F. 2008. . Journal of the American Chemical Society 130(24): 7746鈥�7755. Epub 2008, May 23.
  • Cai, D., Yu, Y., Lan, Y., Dufort, F.J., Xiong, G., Paudel, T., Ren, Z., Wagner, D.J., and Chiles, T.C. 2007. . Biofactors 30(4): 271鈥�277.
  • Faber, A.C. and Chiles, T.C. 2007. . Cell Cycle 6(23): 2982鈥�2989.
  • Dufort, F.J., Bleiman, B., Gumina, M.R., Blair, D., Wagner, D.J., Roberts, M.F., Abu-Amer, Y., and Chiles, T. C. 2007. . Cutting Edge: Journal of Immunology 179: 4953鈥�4957.
  • Chiles, T.C., Mahon, K.P., Potocky, T.B., Blair, D., Roy, M. D., Stewart, K. M., and Kelley, S.O. 2007. . Chemistry & Biology 14(8): 923鈥�930.
  • Doughty, C. A., Bleiman, B. F., Wagner, D. J., Dufort, F. J., Mataraza, J. M., Roberts, M. F., and Chiles, T. C. 2006. . Blood 107(11): 4458鈥�4465.
  • Cai, D., Mataraza, J. M., Qin, Z. H., Huang, Z., Huang, J., Chiles, T. C., Carnahan, D., Kempa, K., and Ren, Z. 2005. . Nature Methods 2(6): 449鈥�454.
Back To Top